Correlation between the MNCD classification-based staging of Parkinson’s disease and quality of life: a cross-sectional study

Parkinson’s disease (PD) is a highly heterogeneous neurodegenerative disorder with varying clinical subtypes. Recently, a novel classification called MNCD (Motor/Non-motor/Cognition/Dependency) has been proposed, which can also include staging based on disease severity. We aim to investigate which staging, the MNCD classification and staging or Hoehn and Yahr (H Y) staging, exhibits a stronger correlation with the 39-item Parkinson’s Disease Questionnaire (PDQ-39). In a cross-sectional study conducted at our single center, 357 PD patients were recruited. Data encompassed scores from various assessments such as the Movement Disorder Society of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Parts I, II, III and IV, Montreal Cognitive Assessment (MoCA), PDQ-39, and the H Y scale. The mean age of these patients was 66.4 ± 9.1 years old, and the majority (54.6