Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery
The AAPS Journal(2024)
摘要
Hepatocytes are one of the most physiologically relevant in vitro liver systems for human translation of clearance and drug-drug interactions (DDI). However, the cell membranes of hepatocytes can limit the entry of certain compounds into the cells for metabolism and DDI. Passive permeability through hepatocytes can be different in vitro and in vivo, which complicates the human translation. Permeabilized hepatocytes offer a useful tool to probe mechanistic understanding of permeability-limited metabolism and DDI. Incubation with saponin of 0.01
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关键词
AO,permeability-limited metabolism,permeabilized hepatocytes,reductases,saponin
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