#262 : Clinical Outcomes of Embryo Transfer After micro-RNA Based Endometrial Receptivity Analysis (MIRA)

Background and Aims: To date, more than 2,500 micro-RNAs (miRNAs) have been discovered and some of which are considered to play important roles in window of implantation (WOI). In this study, we aimed to evaluate the efficacy of a miRNA-based endometrial receptivity analysis (MIRA) in IVF patients. Method: Patients who were planning for frozen-thawed embryo transfer (ET) cycles with a good quality single-blastocyst after at least 1 previous implantation failure history were recruited for the study. Endometrial tissue samples were collected at the mock ET cycle of hormone replacement therapy on day 5 (120 hours) of progesterone administration. Embryo transfer was conducted at the consecutive or the next cycle by reference to the MIRA result. Results: 38 patient samples were collected along with their clinical information such as age, BMI, and implantation failure history. Out of the 38 samples analyzed, MIRA found 84.2% (32/38) to be receptive, 13.2% (5/38) to be pre-receptive, and 2.6% (1/38) to be post-receptive. A total of 33 patients underwent personalized-ET at the time of statistical analysis. The overall clinical pregnancy rate was 81.8% (27/33), and for each endometrial stages were 81.5% (22/27) for receptive, 80.0% (4/5) for pre-receptive, and 100% (1/1) for post-receptive. Higher rates of non-receptivity were seen in patients with higher BMI and patients who were 36 years old or older. Conclusion: Patients who utilized MIRA, have shown good pregnancy rates of 81.8%. Patients with an abnormal BMI have a higher likelihood of experiencing a displaced window of implantation. BMI could also be an additional factor to consider when recommending patients to undergo endometrial receptivity testing in the future, aside from implantation failure history.