Copper-Catalyzed Cyanoalkylation and Trifluoromethylthiolation of Styrene Derivatives via a Visible-Light-Promoted Cross-Coupling

Transition-metal catalyzed difunctionalization of olefins has attracted considerable attention as a method to construct carbon-carbon and carbon-hetero bonds. Herein, the copper-catalyzed three-component radical cross-coupling of oxime esters, styrenes and AgSCF3 through a visible-light-promoted iminyl radical-mediated carbon-carbon bond cleavage strategy has been described. Utilizing low-cost copper salt as both photosensitizers and cross-couplers, this protocol delivers diverse target products, providing a supplementary approach for cyanoalkylation and trifluoromethylthiolation of drug molecules. image