A Covalent-Metal Hybrid-Link Organic Framework Spray for Portable and Instant Therapy of Deep-Degree Burn

Deep burns lead to extensive damage to the dermal layer, necessitating a longer treatment duration than typical skin injuries. Such burn wounds become more susceptible to drug-resistant bacterial infections, thereby complicating and prolonging the therapeutic process. In this study, a unique spray composed of covalent metal hybrid-linked organic frameworks (HLOF) material is developed that effectively eradicates methicillin-resistant Staphylococcus aureus (MRSA) within 20 min by disrupting MRSA's surface electrons, destroying its cell membrane structure, and ultimately causing its demise with an impressive antibacterial rate of 96.7%. This HLOF material exhibited exceptional biological activity and stability. During the wound recovery procedure, HLOF promoted the expression of Vascular endothelial growthfactor(VEGF) to stimulate angiogenesis while inhibiting the proinflammatory factor Tumor necrosis factor alpha (TNF-alpha) expression to eliminate inflammation and further enhance wound repair. This study presents an innovative approach for achieving outstanding antibacterial properties and improved biocompatibility through modifications made to common metal organic frameworks (MOFs), thus expanding their potential applications. Covalent metal hybrid-linked organic frameworks (HLOF) shows excellent dispersibility and stability, and can kill 96.7% of the multidrug-resistant Staphylococcus aureus (MRSA) strains within 20 min without any other method. Normal saline-HLOF (NS-HLOF) can gently and immediately treat MRSA infection after severe burn in mice. It can rapidly eliminate bacteria, inhibit Tumor necrosis factor alpha (TNF-alpha), promote Vascular endothelial growthfactor (VEGF) expression, reduce inflammatory response, accelerate wound tissue repair, and promote wound healing. image