Multi-Physical Field Simulation of Radiofrequency Therapy for Alzheimer’s Disease

Alzheimer’s disease currently has no effective treatment, the reason may be limited to the inherent problems of biochemical means. Radiofrequency wave is a physical means to regulate cells efficiently and noninvasively, which can ameliorate or even reverse the condition of Alzheimer’s disease. To advance radiofrequency therapy for Alzheimer’s disease into clinical application, it is necessary to validate the safety of this therapy and explore the parameter optimization with the human brain environment. Therefore, this study established a concise multi-physical field simulation model of the electromagnetic field and biological heat. The security is preliminarily verified by comparing the specific absorption rate (SAR) and temperature distribution of different power at 918 MHz radio frequency, and a parameter optimization scheme is proposed. This study provides data support for the therapeutic research system design of this therapy and lays a theoretical foundation for further clinical research.