Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice

Allison L Fisher, Sydney Phillips,Chia-Yu Wang, Joao A Paulo,Xia Xiao,Gillian A Moschetta, Adhvaith Sridhar,Joseph D Mancias,Jodie L Babitt

Blood（2024）

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摘要

Iron-mediated induction of BMP6 expression by liver endothelial cells is essential for iron homeostasis regulation. We utilized multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for ZIP8 in regulating BMP6 expression under high-iron conditions.

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