Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data

This study explores regional variations in COVID-19 hospitalization rates, in-hospital mortality, and acute kidney injury (AKI) in England. We investigated the influence of population demographic characteristics, viral strain changes, and therapeutic advances on clinical outcomes. Using hospital episode statistics, we conducted a retrospective cohort study with 749,844 admissions in 337,029 adult patients with laboratory-confirmed COVID-19 infection (March 1, 2020, to March 31, 2021). Multivariable logistic regression identified factors predicting AKI and mortality in COVID-19 hospitalized patients. London had the highest number of COVID-19 admissions (131,338, 18 www.clinicaltrials.gov ) with registration number NCT04579562 on 8/10/2020.