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Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders

Simon C. C. Lucas, Afshan Ahmed, S. Neha Ashraf,Argyrides Argyrou,Matthias R. Bauer,Gian Marco De Donatis,Sylvain Demanze, Frederik Eisele,Lucia Fusani,Andreas Hock,Ganesh Kadamur, Shuyou Li, Abigail Macmillan-Jones,Iacovos N. Michaelides,Christopher Phillips, Marie Rehnstrom, Magdalena Richter,Monica C. Rodrigo-Brenni,Fiona Shilliday, Peng Wang,R. Ian Storer

Journal of Medicinal Chemistry（2024）

Cited 0|Views15

Key words

PROTACs,Protein Degradation,E3 Ubiquitin Ligases

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