Use of Raman and Fourier Transform Infrared Spectroscopy as a Quality Control of 3D printed Linalool Fast Dissolving Oral Films

Oral fast dissolving films (FDFs), have gained attention as an alternative dosage form to solid oral dosage forms such as tablets as their ease of use increases patient acceptability and adherence. This study aimed to investigate spatially offset Raman spectroscopy (SORS) and attenuated total reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy as quality control methods, to assess the suitability of these techniques in hospital pharmacy settings for individualised dosage forms. The findings showed that both Raman spectroscopy and FTIR were successful in identifying the active pharmaceutical ingredient (API) present in the samples however, further investigation with more sensitive techniques such as Surface Enhanced Raman Spectroscopy (SERS) should be conducted.