Expression of the monocarboxylate transporter MCT1 is required for virus- specific mouse CD8+T cell memory development
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA(2024)
摘要
Lactate-proton symporter monocarboxylate transporter 1 (MCT1) facilitates lactic acid export from T cells. Here, we report that MCT1 is mandatory for the development of virus- specific CD8+ T cell memory. MCT1- deficient T cells were exposed to acute pneumovirus (pneumonia virus of mice, PVM) or persistent gamma-herpesvirus (Murid herpesvirus 4, MuHV-4) infection. MCT1 was required for the expansion of virus - specific CD8+ T cells and the control of virus replication in the acute phase of infection. This situation prevented the subsequent development of virus- specific T cell memory, a necessary step in containing virus reactivation during gamma-herpesvirus latency. Instead, persistent active infection drove virus- specific CD8+ T cells toward functional exhaustion, a phenotype typically seen in chronic viral infections. Mechanistically, MCT1 deficiency sequentially impaired lactic acid efflux from activated CD8+ T cells, caused an intracellular acidification inhibiting glycolysis, disrupted nucleotide synthesis in the upstream pentose phosphate pathway, and halted cell proliferation which, ultimately, promoted functional CD8+ T cell exhaustion instead of memory development. Taken together, our data demonstrate that MCT1 expression is mandatory for inducing T cell memory and controlling viral infection by CD8+ T cells.
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关键词
T cell memory development,T cell exhaustion,lactate transport,monocarboxylate transporters (MCTs),virus latency
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