Comprehensive Analysis of the Role of Forkhead Box J3(FOXJ3)in Human Cancers

Forkhead box J3(FOXJ3)is a member of the forkhead box(Fox)family.Recently,increasing evidence has revealed the rela-tionship between Fox family members and cancer.FOXJ3 is involved in various types of cancer,including lung cancer,tongue squamous carcinoma,and prostate cancer;however,a comprehensive pan-cancer analysis of FOXJ3 remains lacking.Here,we explored the function of FOXJ3 across cancers using online websites and databases including TIMER2.0,SangerBox,UALCAN,GEPIA2.0,cBioPortal,Cancer-SEA,STRING,BioGRID and Metascape to analyze the role of FOXJ3 in cancers.Abnormal expression of FOXJ3 was found in various tu-mors.The genetic alteration percentage in tumors was determined,and elevated FOXJ3 expression was found to be associated with worse overall survival in brain lower grade glioma(LGG),liver hepatocellular carcinoma(LIHC),sarcoma(SARC)and thyroid carcinoma.El-evated FOXJ3 expression was related to worse prognosis with disease-free survival in adrenocortical carcinoma,LGG and LIHC.FOXJ3 expression was related to immune infiltration in several cancers.Enrichment analysis showed that histone modification,the TGF-β signal-ing pathway,and chromatin organization were the top three enriched ontology clusters of the top 100 similar genes of FOXJ3.Our pan-cancer analysis provides comprehensive insights into FOXJ3 from the perspective of bioinformatics in different cancers,where it serves as a potential biomarker for prognosis,especially in LGG and LIHC.FOXJ3 is also correlated with immune infiltrates in certain human tu-mors.