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Feasibility of Next-generation Sequencing of Liquid Biopsy (circulating Tumor DNA) Samples and Tumor Tissue from Patients with Metastatic Prostate Cancer in a Real-world Clinical Setting in Germany

Philipp Mandel,Benedikt Hoeh,Clara Humke,Claudia Doering,Mike Wenzel,Cristina Cano Garcia, Nina Fuhr,Florestan Koll,Anne Fassl,Derya Tilki,Thomas Steuber,Iris Faull,Jan Jeroch,Silvana Ebner,Christina Schmitt,Henning Reis,Jens Koellermann,Konstantinos D. Kokkaliaris,Melanie C. Demes,Felix K. H. Chun,Peter J. Wild

EUROPEAN UROLOGY FOCUS（2024）

Cited 2|Views19
Key words
Key findings and limitations,TT NGS was successful in 44/50 patients (88%),with patho- genic BRCA1/2 alterations detected in four (9%). LB NGS was successful in all 50 patients (100%),with BRCA1/2 alterations detected in ten (20%). In a subgroup analysis for the 44
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