Green synthesis of 2-thioxo-4-quinazolinones from 2-aminobenzamide and isothiocyanates

Novel green synthesis protocols of 2-thioxo-4-quinazolinones starting from 2-aminobenzamide and isothiocyanates have been reported. Method A: the reaction was carried out at 60 degrees C, in water, reaction time of 16 h. Method B: The reaction was carried out under solvent-free conditions at 100 degrees C for 16 h. Based on these methods, six 2-thixo-4-quinazolinone derivatives were synthesized with good yield. These methods have advantages, including no use of organic solvents, additives that avoid the generation of toxic waste, simple processes, cost-effectiveness, good yields, ease of product isolation, and purification. image