-Glucosidase Inhibitory Components from Garcinia pedunculata Fruits

From Garcinia pedunculata Roxb. fruits, two undescribed aromatic compounds including a benzofuran and a depsidone derivative, and a new natural product, together with four known compounds were isolated. Through the analysis of spectroscopic data, high resolution mass spectrum and calculated nuclear magnetic resonance, their structures were determined. The alpha-glucosidase inhibitory activity of the isolates was evaluated. And compound 3 exhibited a moderate inhibitory effect on alpha-glucosidase. The molecular docking of compound 3 was performed to elucidate the interaction with alpha-glucosidase.