Correction: The spectrum of TP53 mutations in Rwandan patients with gastric cancer

Augustin Nzitakera, Jean Bosco Surwumwe, Ella Larissa Ndoricyimpaye, Schifra Uwamungu, Delphine Uwamariya,Felix Manirakiza,Marie Claire Ndayisaba,Gervais Ntakirutimana, Benoit Seminega,Vincent Dusabejambo, Eric Rutaganda, Placide Kamali, François Ngabonziza,Rei Ishikawa, Belson Rugwizangoga,Yuji Iwashita,Hidetaka Yamada,Kimio Yoshimura,Haruhiko Sugimura,Kazuya Shinmura

Genes and Environment（2024）

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摘要

Gastric cancer is the sixth most frequently diagnosed cancer and third in causing cancer-related death globally. The most frequently mutated gene in human cancers is TP53, which plays a pivotal role in cancer initiation and progression. In Africa, particularly in Rwanda, data on TP53 mutations are lacking. Therefore, this study intended to obtain TP53 mutation status in Rwandan patients with gastric cancer. Formalin-fixed paraffin-embedded tissue blocks of 95 Rwandan patients with histopathologically proven gastric carcinoma were obtained from the University Teaching Hospital of Kigali. After DNA extraction, all coding regions of the TP53 gene and the exon–intron boundary region of TP53 were sequenced using the Sanger sequencing. Mutated TP53 were observed in 24 (25.3

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关键词

TP53,Mutation spectrum,Mutation pattern,Genetic analysis,Gastric cancer,Rwanda,Africa

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