Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties

Acyl fluorides have emerged as versatile reagents in various synthetic endeavors, offering a range of advantages over their counterparts, acyl chlorides. This study delves into the properties and reactivity of acyl fluorides, particularly their reaction with amines and alcohols, to elucidate their distinct characteristics. We also introduce a facile and practical synthesis of acyl fluorides from a stable solution of CF3O- salt. Additionally, we establish an efficient one-pot process for the direct preparation of amides or esters from corresponding acids and amines or alcohols, showcasing the remarkable efficiency of acyl fluorides in these transformations. The facile and safe synthesis of acyl fluorides, under metal-free and cost-effective conditions, presents a remarkable advance in organic synthesis. These versatile reagents, endowed with distinct reactivity owing to the fluorine atom, offer a wealth of possibilities for further utilization. image