An observational study of haemophilia A patients without inhibitors using the French national claims (SNDS) database

Objectives:To describe clinical characteristics, factor consumption, and events of interest in patients with haemophilia A without inhibitors receiving prophylaxis in France, and the clinical impact of switching to Elocta (R) in this population.Methods:This retrospective, observational study using the Systeme National des Donnees de Sante database, analysed data from patients with haemophilia A without inhibitors using prophylactic factor VIII (FVIII) replacement therapy during 2016-2019. Clinical characteristics, treatment patterns and switches, factor consumption, and rate of events of interest were determined. In a sub-cohort of patients treated with Elocta (R), clinical characteristics, factor consumption, and rate of events of interest before and after switching to Elocta (R) were compared.Results:For 545 patients, with mean age (standard deviation [SD]) 25.4 (17.8) years, Elocta (R) was the most used treatment. Bleeding events and articular non-bleeding events leading to hospitalization occurred in 15.4% and 13.9% of patients, respectively, and 9.9% of patients had surgeries or procedures related to haemophilic arthropathy. The mean (SD) FVIII product consumption was 344 (93) IU/kg/month for extended half-life treatment, and 331 (98) IU/kg/month for standard half-life products. For the sub-cohort of 146 patients, bleeding events (SD) decreased from 0.32 (2.2) to 0.09 (0.42) events/patient/year (p = 0.227) after switching to Elocta (R). There was no statistically significant difference in rates of factor consumption or articular non-bleeding events before and after initiation of Elocta (R).Conclusion:This study provides real-world insights that advance the understanding of treatment patterns and events of interest in patients with haemophilia A on prophylactic regimens in France.