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Use of a Dynamic Flow Platform to Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib

Michael J. Di Maso,Jeffrey T. Kuethe,Karthik Narsimhan, Matthew Burris,Cheol K. Chung,Michael DiBenedetto,Jacob H. Forstater,Shane T. Grosser,Nadine Kuhl,Francois Levesque, Anne Maguire,Kevin M. Maloney,Jonathan P. McMullen,Christopher K. Prier,Ji Qi,Nelo R. Rivera,Zhixun Wang,Brian M. Wyvratt,Daniel Zewge

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2023）

引用 3|浏览16
关键词
flow chemistry,biocatalysis,transaminase,immobilized enzyme,packed bed reactor,data-richexperimentation
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