Electrochemical synthesis of 2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzamides with ethylene glycol as the methylene source

Yue Zhang, Mingzhu Liu, Kun Zhao,Muqiong Li,Liang Xu, Zhichao Li


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In this study, an electrochemical method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones is presented. The protocol utilizes ethylene glycol as the methylene C1 source to cyclize with 2-aminobenzamides. Notably, this cyclization reaction proceeds efficiently and conveniently under room temperature, without the need for any homogeneous metal catalysts, external oxidants, acids or bases. Via this relatively simple and green approach, an array of structurally diverse N,N-disubstituted 2,3-dihydroquinazolin-4(1H)-ones can be obtained.
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2,3-Dihydroquinazolin-4(1H)-ones,Electrochemical synthesis,Ethylene glycol
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