Innovative colorimetric detection of clinical Gram-negative bacteria using low-cost bacteriostatic barbiturate polymers
Materials Today Chemistry(2024)
摘要
This study introduces the synergistic antibacterial activity derived from the combination of barbituric acid derivatives with PVC, PMMA and PMMMA polymers. The barbiturates - C1, C2, and C3, exhibit potent Minimum Inhibitory Concentration (MIC) values and clear selectivity towards Gram-positive bacteria in solution, resulting in inhibitory activity at exceptionally low concentrations (0.19–0.0015 μg/mL). By integrating these barbiturates within polymeric matrices, an advanced antibacterial polymer was obtained. This novel material facilitates the dual benefit of detecting Gram-negative bacterial colonies via colorimetric alterations, while simultaneously providing a broad-spectrum antibacterial approach, effective against both Gram-positive and Gram-negative bacteria. The potential of these barbiturate-enhanced polymers is substantial, not least because of their cost-effective nature. Their inherent feature of enabling naked-eye selective alterations, positions them as an efficient, onsite tool for monitoring contamination by E. coli and P. aeruginosa in clinical environments. Thus, these polymers open a new horizon for innovative, rapid, and low-cost strategies in microbial contamination control and patient safety.
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关键词
Barbiturate,Colorimetric detection,Antibacterial polymers,Gram-negative bacteria,PVC,PMMA,PMMMA
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