Effectiveness comparison of genicular nerve ablation for knee osteoarthritic versus post-total knee arthroplasty pain

Background Genicular nerve radiofrequency ablation (GNRFA) is a popular and effective procedure to treat arthritic knee pain. For refractory arthritic pain that fails conservative treatment, total knee arthroplasty (TKA) has been an excellent option. Unfortunately, 15–30% of people who undergo a TKA continue to experience pain and stiffness in the knee. The treatment options for post-TKA knee pain are limited. Pain providers have been trialing GNRFA on this pain condition. However, convincing evidence of its efficacy in treating post-TKA pain is still lacking. Methods This is a retrospective study of 73 patients who had undergone genicular nerve RFA, 46 (63.01%) with osteoarthritic pain, and 27 (36.99%) with post-TKA pain. We compared the outcomes (pain relief, function, and complications) between these two groups at 3 months and 6 months after RFA. Results Before RFA, there was no significant difference in initial pain and functional level between these two groups. After RFA, the two groups had comparable pain relief at 3 months (p = 0.68) and 6 months (p = 0.53), and similar functionality at 3 months (p = 0.36) and 6 months (p = 0.65).The overall success rate (≥50% pain relief after RFA) was 80.82%, 95% CI: 70.34%–88.22% (osteoarthritic group 80.43%, 95% CI: 66.83%–89.35%, post-TKA 81.48%, 95% CI: 63.30%–91.82%, P = 0.91) at 3-month follow-up and 56.16%, 95% CI: 44.76%–66.95% (osteoarthritic group 56.52%, 95% CI: 42.25%–69.79%, post-TKA 55.56%, 95% CI: 37.31%–72.41%, P = 0.94) at 6-month follow-up.There were no reported complications in either group. Conclusions Genicular Nerve Radiofrequency Ablation (GNRFA) holds the potential to be equally effective for both post-TKA knee pain and osteoarthritic knee pain.