Persistence of vitamin D deficiency among Italian patients with acute myocardial infarction

Background and Aims Vitamin D deficiency is a common cardiovascular risk factor associated with the development of atherosclerosis. We evaluated changes in 25(OH)D concentrations in 1510 patients with acute myocardial infarction (AMI) over a long observation period, including the COVID-19 pandemic. Methods and Results Patients were separated into four groups according to the year of enrolment, group 1 (2009-2010), group 2 (2014-2016), group 3 (2017-2019), and group 4 (2020-2022).The median 25(OH)D concentration in the overall cohort was 17.15 (10.3-24.7) ng/mL. The median plasma concentrations of 25(OH)D for groups 1, 2, 3, and 4 were 14.45 (7.73 - 22.58) ng/mL, 17.3 ng/mL (10.33 – 24.2), 18.95 (11.6 – 26.73) ng/mL and 19.05 (12.5 – 27.3) ng/mL, respectively. Although 25(OH)D levels increased over the years, the prevalence of vitamin D deficiency remained high in each group (68.4%, 61.4%, 53.8%, and 52% respectively). Hypovitaminosis D was predicted by the season influence (OR:2.03, p<0.0001), higher body mass index (OR:1.25; p=0.001), diabetes mellitus (OR:1.54; p=0.001), smoking (OR:1.47; p=0.001), older age (OR:1.07; p=0.008), higher triglycerides levels (OR:1.02; p=0.01), and female gender (OR:1.3; p=0.038). After multivariable adjustment, vitamin D≤20 ng/mL was an independent predictor of mortality. Conclusion Vitamin D deficiency is highly prevalent and persistent in patients with AMI despite a trend towards increasing 25(OH)D concentrations over the years. The frequent lockdowns did not reduce the levels of 25(OH)D in the fourth group. Low levels of 25(OH)D are an independent predictor of mortality.