IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma
LEUKEMIA RESEARCH REPORTS(2024)
摘要
IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed IGLL5 mRNA with C lambda 1 segment. JQ1 treatment resulted in down-expression of IGLL5, indicating that IGLL5 is controlled by SE. IGLL5 knockdown induced cell death with down-expression of MYC. Our results suggested that IGLL5 might have a role in survival of mature B-cell tumors and involvement in MYC expression. (100 words)
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关键词
Mature b-cell lymphoma,Immunoglobulin lambda like polypeptide 5,(igll5),Super-enhancer SiRNA
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