Five new sesquiterpenoids isolated from Dictamnus dasycarpus Turcz

Five new sesquiterpenoids, dictamtrinorguaianols E and F (1-2), and dictameudesmnosides F, G, and H (3-5), along with seven known sesquiterpenoids (6-12) were isolated from Dictamnus dasycarpus Turcz. The structures of all new compounds were characterized by spectroscopic methods, including UV, IR, HR-ESI-MS, and 1D and 2D NMR. The In -vitro anti -proliferative activities of all the compounds against two human cancer cell lines (SW982 and A549) were evaluated by CCK-8 assay. Compounds 1 and 4 showed medium anti -proliferative activity against SW982 cells, with IC50 values of 3.49 +/- 0.10 and 6.42 +/- 1.23 mu M, respectively. Additionally, compounds 2, 7, and 8 exhibited medium anti -proliferative activity against A549 cells, with IC50 values ranging from 0.80 +/- 0.05 to 6.60 +/- 0.46 mu M.