Specific IgA, But Not IgG, in Human Milk From COVID-19-infected Mothers Neutralizes SARS-CoV-2.

The Pediatric infectious disease journal(2024)

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摘要
This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA. Depletion of IgA, but not IgG, from milk samples completely abolished the ability of human milk to neutralize severe acute respiratory syndrome coronavirus 2.
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