SLAM medical imaging enabled by pre-chirp and gain jointly managed Yb-fiber laser

We demonstrate a pre -chirp and gain jointly managed Yb-fiber laser that drives simultaneous label -free autofluorescence-multiharmonic (SLAM) medical imaging. We show that a gain managed Yb-fiber amplifier produces high -quality compressed pulses when the seeding pulses exhibit proper negative pre -chirp. The resulting laser source can generate 43 -MHz, 34-fs pulses centered at 1110 nm with more than 90-nJ energy. We apply this ultrafast source to SLAM imaging of cellular and extracellular components in various human tissues of intestinal adenocarcinoma, lung adenocarcinoma, and liver. (c) 2024 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement