CALR -mutated patients with low allele burden represent a specific subtype of essential thrombocythemia: A study on behalf of FIM and GBMHM Laure Aubin , Ruben Vilas Boas , Rafael Daltro De Oliveira , Valoris Le Brun , Marion Divoux , Jerome Rey , Olivier Mansier , Jean-Christophe Ianotto , Cedric Pastoret , Anne Desmares , Anne Murati , Veronique de Mas , Suzanne Tavitian , Francois Girodon , Juliette Soret Dulphy , Nabih Maslah , Valerie Goncalves Monteiro , Francoise Boyer , Corentin Orvain , Dana Ranta , Emilie Cayssials , Lenaig Le Clech , Christophe Nicol , Camille Rottier , Teresa Botin Lopez , Brice Castel , Patrick Rispal , Guillaume Beziat , Charles Bescond , Kamel Laribi , Lina Benajiba , Valerie Ugo , Eric Lippert , Laurane Cottin , Damien Luque Paz AMERICAN JOURNAL OF HEMATOLOGY（2024）
摘要
A low allele burden (i.e., <20%) of the CALR driver mutation is found in 10.8% of CALR-mutated MPNs, mostly in essential thrombocythemia, and correlates with a milder phenotype and a more indolent evolution compared to patients with an allele burden ≥20%.
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