Modeling Acute Myeloid Leukemia Using StarPEG-Heparin Hydrogels.

P Lewen Holloway,Akhilandeshwari Ravichandran,Julien Clegg,Claudia Bruedigam,Laura J Bray

Methods in molecular biology (Clifton, N.J.)（2024）

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摘要

Biomimetic semi-synthetic hydrogels formed from a combination of star-shaped poly(ethylene glycol) (starPEG) and the glycosaminoglycan, heparin, allows for the three-dimensional (3D) culture of various cells and tissues. In this chapter, we describe methods for the use of starPEG-heparin hydrogels to cultivate primary and immortalized human acute myeloid leukemia (AML) cells. The resulting 3D culture models allow for the study of AML development and response to chemotherapeutic agents.

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