Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI

Laurel A. Screven,Caroline B. Pantazis, Katherine M. Andersh, Samantha Hong, Dan Vitale, Erika Lara, Ray Yueh Ku, Peter Heutink,Jason Meyer, Kelley Faber,Kwangsik Nho, Andrew J. Saykin,Tatiana M. Foroud, Mike A. Nalls,Cornelis Blauwendraat, Andrew Singleton,Priyanka S. Narayan

NEURON（2024）

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摘要

The iDA Project (iPSCs to Study Diversity in Alzheimer's and Alzheimer's Disease-related Dementias) is generating 200 induced pluripotent stem cell lines from Alzheimer's Disease Neuroimaging Initiative participants. These lines are sex balanced, include common APOE genotypes, span disease stages, and are ancestrally diverse. Cell lines and characterization data will be shared openly.

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