Fabrication and characterization of biomimetic injectable HA/GT-OSA composites for bone regeneration

To address the issue of limited bone repair efficacy, a novel biomimetic HA/GT-OSA composite was synthesized through crosslinking gelatin (GT) with oxidized sodium alginate (OSA) for encapsulating hydroxyapatite (HA). The physicochemical properties of the composite were assessed using SEM, XRD, and FT-IR analyses. The biodegradability and biocompatibility of the HA/GT-OSA were confirmed via simulated body fluid (SBF) degradation testing and toxicity evaluation. Moreover, the HA/GT-OSA composites showed excellent bone regeneration performance in the SD rats intracranial bone repair, highlighting their immense potential for treating irregular bone defects and facilitating minimally invasive surgical implantation.