Bacterial pseudaminic acid binding to Siglec-10 induces a macrophage interleukin-10 response and suppresses phagocytosis

Pseudaminic acid (Pse) on pathogenic bacteria exopolysaccharide engages with the sialic acid-binding immunoglobulin-type lectin (Siglec)-10 receptor on macrophages via the critical 7-N-acetyl group. This binding stimulates macrophages to secrete interleukin 10 that suppresses phagocytosis against bacteria, but can be reverted by blocking Pse-Siglec-10 interaction with Pse-binding protein as a promising therapy. The interaction between pseudaminic acid (Pse) on pathogenic bacteria exopolysaccharide and sialic acid-binding immunoglobulin-type lectin (Siglec)-10 receptor on macrophages induces interleukin 10 (IL-10) release to suppress phagocytosis.