Comparing Robotic, Thoracoscopic, and Open Segmentectomy: A National Cancer Database Analysis

Introduction: Minimally invasive approaches to lung resection have become widely acceptable and more recently, segmentectomy has demonstrated equivalent oncologic outcomes when compared to lobectomy for early -stage non -small cell lung cancer (NSCLC). However, studies comparing outcomes following segmentectomy by different surgical approaches are lacking. Our objective was to investigate the outcomes of patients undergoing robotic, video -assisted thoracoscopic surgery (VATS), or open segmentectomy for NSCLC using the National Cancer Database. Methods: NSCLC patients with clinical stage I who underwent segmentectomy from 2010 to 2016 were identified. After propensity -score matching (1:4:1), multivariate logistic regression analyses were performed to determine predictors of 30-d readmissions, 90d mortality, and overall survival. Results: 22,792 patients met study inclusion. After matching, approaches included robotic (n = 2493; 17%), VATS (n = 9972; 66%), and open (n = 2493; 17%). An open approach was associated with higher 30-d readmissions (7% open versus 5.5% VATS versus 5.6% robot, P = 0.033) and 90-d mortality (4.4% open versus 2.2% VATS versus 2.5% robot, P < 0.001). A robotic approach was associated with improved 5-y survival (50% open versus 58% VATS versus 63% robot, P < 0.001). Conclusions: For patients with clinical stage I NSCLC undergoing segmentectomy, compared to the open approach, a VATS approach was associated with lower 30-d readmission and 90-d mortality. A robotic approach was associated with improved 5-y survival compared to open and VATS approaches when matched. Additional studies are necessary to determine if unrecognized covariates contribute to these differences. (c) 2024 Elsevier Inc. All rights reserved.