The Versatile Natural Product Enzymology of Marine Microbial Communities

Marine microbial communities are a wellspring of biochemical transformations, with discovery fueled by the ever-expanding development of biotechnological methodologies. Meta-omic strategies-from genome-based studies to enzymology and molecular-level investigations-have shed light on the involvement of microbial dark matter in the biosynthesis of bioactive metabolites. Herein, we describe the enzymology and biosynthesis of natural products derived from marine invertebrates, highlighting the diversity of this vast biochemical resource.