New cationic linear N-chloramines based on N-t-butylamide: chemical synthesis and antibacterial application

For the first time, we synthesized three types of cationic linear N-chloramines that do not use the popular 5,5-dimethyl hydantoin scaffold. The characterized N-chloramines displayed satisfactory bactericidal activity, and the long-chain analogues exerted greatly elevated biocidal efficacy due to "synergistic" antibacterial actions between the N-Cl moiety and long chain cationic center. Our study provides highly efficacious biocides as well as paving the way for producing novel N-chloramines that exclude toxic cyanide salts.