Cobalt-catalyzed aminoalkylative carbonylation of alkenes toward direct synthesis of -amino acid derivatives and peptides

gamma-Amino acids and peptides analogues are common constituents of building blocks for numerous biologically active molecules, pharmaceuticals, and natural products. In particular, gamma-amino acids are providing with better metabolic stability than alpha-amino acids. Herein we report a multicomponent carbonylation technology that combines readily available amides, alkenes, and the feedstock gas carbon monoxide to build architecturally complex and functionally diverse gamma-amino acid derivatives in a single step by the implementation of radical relay catalysis. This transformation can also be used as a late-stage functionalization strategy to deliver complex, advanced gamma-amino acid products for pharmaceutical and other areas. gamma-Amino acids and peptides analogues are common constituents of building blocks for numerous biologically active molecules, pharmaceuticals, and natural products. Here, the authors developed a multicomponent carbonylation technology that combines readily available amides, alkenes, and the feedstock gas carbon monoxide to build gamma-amino acid derivatives in a single step.