Direct Enol Ether Metalation-Negishi Coupling Strategy To Prepare -Heteroaryl Enol Ethers

Feng Peng, Kailin Liu,Huangguang Zhang, Fuchun Xu, Yanan Liu, Gao Shang

ORGANIC LETTERS（2023）

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摘要

A robust direct enol ether metalation-Negishi coupling using heteroaryl halides catalyzed by the palladium-Cy-DPEPhos system is reported. This method, which was demonstrated with a broad substrate scope, is a highly complementary method to the existing Heck coupling of synthesizing challenging alpha-heteroaryl-alpha-alkoxy alkenes.

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