Incidental Detection of ⁶⁸Ga-DOTA-RGD-2 Uptake in Uterine Fibroid

Uterine fibroids are benign tumors originating from the smooth muscle cells of the myometrium seen in approximately 20%-50% of women of reproductive age. The Arg-Gly-Asp (RGD) binds to alpha v beta 3 integrin expressed on the surface of angiogenic blood vessels or tumor cells. F-18-FDG PET/CT has been used to evaluate uterine fibroids, with moderate F-18-FDG uptake. However, angiogenesis imaging in uterine fibroids has not been evaluated. The present case presents a rare finding of RGD uptake in the uterine fibroid on Ga-68-DOTA-RGD-2 PET/CT in a patient who underwent angiogenesis imaging for left ankle joint pain and swelling.