A th A review: the mechansm of pant-derved poysacchardes on osteobasts and osteocasts h i f pl td i d p ly h id t bl t d t l t

Bone loss and deterioration of bone microarchitecture would increase the bone fragility and fracture risk, Bone loss and deteriato of bone microarchitecture would increase th bone fragility n fractre risk, leading to the osteoporosis. More and more evidences proved that plant-derived polysaccharides could have leading to the osteoporosis More and more evidences proved that plant-derived polysaccharides could hav a remarkable influence on osteoblasts and osteoclasts, exerting anti-osteoporosis effects. According to the previous resarch, the xtract ofCiboium barumoz, Achyranthes bidentaa, Curculigo orchioides, Epimedium a remarkable influence on osteoblasts and osteocl sts, exerting anti-oste porosis effects. Acco ding to the prous research, the extract oCibotium barumoz,Achyranthes bidentata,Curculigo orchioides,Epimedium brevicornum, Angelica sinensis, Polygonatum sibiricum, Dendrobium officinale, Morinda officinalis, Nelumbo nucifera, Diospyros kaki, Hordeum vulgare, Cistanche deserticola, Commiphora Myrrhaand other plant-brevicornum, Angeli a sinensis,Polygonatum sibiricum, Dendrobium officinale,Mo inda officinalis,Nelumbo nucfra,Diospyros kaki Horeum vulgare,Cistanche deserticla,Commphora Myrrhaand other plant-derived polysaccharides could benefit to the osteoblasts and osteoclasts. The essential mechanisms are manly related to the activation or inhibition of many factors, including runt-rlated transcriptio factor 2 derived polysaccharides could benefit to the osteoblasts and osteoclasts The essential mechan sms a e maily r lated to t e actvation or inhibition f many facto s, including runt-related ranscription factor 2 (Runx2), beta-catenin, osterix (Osx), activator protein-1 (AP-1), osteocalcin (OCN/BGP), alkaline phosphatase ALP), osteopotn (OPN), bone morphogenetic protein (BMP), phosphatidylinositol 3-kinse (PI3K)/C-Jun (Runx2), beta-catenin, osterix (Osx), activator protein-1 (AP-1), oseocalcin (OCN/BGP), alkaline phosphatase N-terminal kinase JNK)/extracellular regulated protein kinase (ERK), osteoprotegern (OPG), receptor (ALP), osteopontin (OPN), bone morphogenetic protein (BMP), phospha dylinositol 3-kinase (PI3K)/C-Jun N-terminal kinase (JNK)/extracellular egulated protein kinase (ERK), osteoprotegerin OPG), r cept activator of nuclear factor-kappa B (RANK), monocyte/macrophage colony-stimulating factor (M-CSF), tumor necrosis factor receptor-associated factor 6 (TRAF-6), eceptor activator of nuclear factor (NF)-kappa B ligand activator of nuclear factor-kappa B (RANK), monocyte/ma rophage colony-stimulating factor (M-CSF), tumor necrosis fa tor rceptor-associated factor 6 (TRAF-6), recep or actvator of nuclear facor (NF)-kappa B ligand (RANKL), nuclear factor of activated T cells 1 (NFATc1), c-Fos, matrix metallopeptidase-9 (MMP-9), glycogen sythase kinase 3 beta (GSK3 beta)/beta-catnin, nuclear factor E2-related factor 2 (Nrf2), as well as these (RANKL), nuclear factor of activated T cells (NFATc1), c-Fos, matrix metallopeptidase-9 (MMP-9), related pathway, such as Wnt/beta-catenin, BMP-2/SMAD1/5/8, PI3K/AKT, OPG/RANKL/RANK, NF-kappa B, glycogen synthas kinase 3 beta (GSK3 beta)/beta- atenin, nuclear factor E2-related actor 2 (Nrf2), as well as these MAPKs, etc. These plant-derived polysaccharides could improve the dynamic balance of bone formation and related pathways, such as Wnt/beta-catenin, BMP-2/SMAD1/5/8, PI3K/AKT, OPG/RANKL/RANK, NF kappa B, resorption hrough promoting the differentiation and maturatin of osteoblast or inhibiting its formation. The MAPKs, etc. These plant-derived polysaccharides could improve the dynamic balance of bon formation and viewed plant-derived polysaccharides and their regulating mechanisms on the osteoclasts and oseoblasts resorption through promoting the differentiation and maturation of osteoblast or inhibiting its formation. The provide the evidences for the development of osteoporosis therapeutics reviewed p ant-derived polysaccharides and their regulating mechani . (c) 2024 Beijing Academy of Food . Science. Publishing services by Elsevie r .. B.V. on behalf of KeAi Communications Co Ltd This is an open access article under the CC BY-NC-ND license ..--Communications Co., Ltd. This is an open access article under the CC BY NC ND license (http://creativecommons org/license /by nc nd/40/) :.--.. (http://creativecommons org/licenses/by nc nd/4 0/)