In-field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019
INFLUENZA AND OTHER RESPIRATORY VIRUSES(2024)
摘要
BackgroundIn 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak.MethodAs it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B/VIC lineage variant viruses.ResultsThe investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real-time RT-PCR).ConclusionThis work underscores the value of portable platforms for rapid, onsite pathogen characterization.
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关键词
amino acid deletion,B/Victoria lineage,in-field detection,influenza outbreak
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