Dihydrophenanthro[b]furan derivatives from the tubers of Bletilla striata
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH(2024)
摘要
Two pairs of new dihydrophenanthro[b]furan enantiomers blephebibnols G-H (1-2), one new dihydrophenanthro[b]furan derivative blephebibnol I (3), along with four known analogues (4-7), were isolated from the tubers of Bletilla striata. Their structures including the absolute configurations were determined by the combination of spectroscopic data analysis, ECD and NMR calculations. Compounds 1a, 1b, and 2b showed inhibition of NO production in LPS-stimulated BV-2 cells, with IC50 values ranging from 4.11 to 14.65 mu M. Further mechanistic study revealed that 1a suppressed the phosphorylation of p65 subunit to regulate the NF-kappa B signaling pathway. In addition, some compounds displayed selective cytotoxic activities against HCT-116, HepG2, A549, or HGC27 cancer cell lines with IC50 values ranging from 0.1 to 8.23 mu M.{GRAPHIACAL ABSTRACT}
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关键词
Orchidaceae,Bletilla striata,dihydrophenanthro[b]furan derivatives,anti-neuroinflammatory activity,NF-kappa B signaling pathway,cytotoxic activity
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