Pro-angiogenic effect of a synthetic Cu(II) complex [CuII(L)2] [LH = tautomeric thiolate form of 2-ethoxybenzaldehyde-N (4)-dihexyl-3-thiosemicarbazone]

Synthesis and structural characterization of a thiosemicarbazone derivative of Cu(II) [CuII(L)2] [LH = tautomeric thiolate form of 2-ethoxybenzaldehyde-N(4)-dihexyl-3-thiosemicarbazone (L1)] (1) is reported. From the structural characterization data, the metal centre in 1 is found to have in square planar geometry. Both the free ligand (L1) and the metal complex (1) showed pro-angiogenic activity on fertilized chicken eggs. In Chorio-Allantoic Membrane (CAM) assay, L1 was found to promote blood capillary growth by 31.5% in 24 h, whereas for 1 it was 40.0%. In aortic arch assay also, 1 showed better angiogenic potential than the free L1.