Visible-Light Photoredox-Catalyzed Intermolecular -Aminomethyl/Carboxylative Dearomatization of Indoles with CO₂ and -Aminoalkyl Radical Precursors

Disclosed here is a visible-light photoredox-catalyzed intermolecular sequential alpha-aminomethyl/carboxylative dearomatization of indoles with CO2 and alpha-aminoalkyl radical precursors, affording a series of functionalized indoline-3-carboxylic acids and lactams in good yields with high regioselectivity. This multicomponent reaction provides a green and facile method for the synthesis of diverse functionalized indolines by using CO2 as the carboxylic and carbonyl source.