In vivo macrophage engineering as novel therapeutic strategy against liver metastasis.
Trends in cancer(2024)
摘要
In a recent study, Kerzel et al. report a novel therapeutic strategy to engineer tumor-associated macrophages (TAMs) in vivo by inducing the expression of IFNα in these cells. This approach enables improved antigen presentation and T cell activation, leading to controlled tumor growth in multiple murine models of liver metastasis.
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