Behavioral resistance to insecticides: current understanding, challenges, and future directions

Identifying and understanding behavioral resistance to insecticides is vital for maintaining global food security, public health, and ecological balance. Behavioral resistance has been documented to occur in a multitude of insect taxa dating back to the 1940s, but has not received significant research attention due primarily to the complexities of studying insect behavior and a lack of any clear definition of behavioral resistance. In recent years, a systematic effort to investigate the mechanism(s) of behavioral resistance in pest taxa (e.g. the German cockroach and the house fly) has been undertaken. Here, we practically define behavioral resistance, describe the efforts taken by research groups to elucidate resistance mechanisms, and provide insight on designing appropriate bioassays for investigating behavioral resistance mechanisms in the future.