HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity

•Reduced RBC is the phenotype of early hematotoxicity from low-level benzene exposure.•HIF-1α regulates CCL3/immunosurveillance against damaged cells and iron homeostasis.•Low-level benzene-induced depletion of m6A promotes the mRNA stability of NFKBIA.•HIF-1α/m6A/NF-κB/CCL3 axis in low-level benzene-associated anemia and leukemia.•Epigenetic effect of real-world benzene links with immunoregulation and RBC changes.