Recent advances in the study of knockdown resistance mutations in Aedes mosquitoes with a focus on several remarkable mutations

The Aedes mosquito, which transmits the dengue fever virus and other viruses, has acquired resistance to pyrethroid insecticides in a naturally selective manner. Massive use of insecticides has led to the worldwide expansion of resistant populations. The major factor in pyrethroid resistance is knockdown resistance (kdr) caused by amino acid mutation(s) in the voltage-gated sodium channel, which is the target site of this insecticide group. Some kdr mutations can lead to a dramatic increase in resistance, and multiple mutations can increase the level of pyrethroid resistance by 10 to several-hundred. In this review, we summarize the kdr identified in Aedes mosquitoes with a focus on the recent advances in the study of kdr.