Unlocking the role of dorsal hippocampal α4β2 nicotinic acetylcholine receptors in Ethanol-Induced conditioned place preference in mice

Paola Palombo, Roberta Maeda, Caroline Riberti Zaniboni,Sheila Antonagi Engi,Thais Yokoyama,Natalia Bonetti Bertagna, Augusto Anesio,Paula Cristina Bianchi, Thamires Righi, Gabrielle Emily Boaventura Tavares, Caden Souccar, Fernando Bezerra Romualdo da Silva, Fabio Cardoso Cruz

Neuroscience letters（2024）

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摘要

•Ethanol-induced Conditioned Place Preference (CPP) correlates with an increase in Fos-positive cells in the dorsal hippocampus.•Nicotinic receptors play a role in both the rewarding effects and memory formation associated with ethanol.•The administration of DHBE successfully blocked ethanol-induced CPP without affecting locomotor activity.

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nAChR,CPP,DHBE,PBS

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