rBet v 1a-BanLecwt induce upregulation of IL-10 and IFN-γ gene expression in Caco-2/THP-1 co-culture and secretion of IL-10 and IFN-γ/IL-4 levels in PBMCs of birch pollen allergic donors

Isidora Protić-Rosić,Zorana Lopandić,Dragan Popović, Gordan Blagojević,Marija Gavrović-Jankulović

International immunopharmacology（2024）

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摘要

•rBet v 1a-BanLecwt induce upregulation of IL-10 gene expression in Caco-2/THP-1 co-culture.•rBet v 1a-BanLecwt induce upregulation of IFNγ gene expression in Caco-2/THP-1 co-culture.•rBet v 1a-BanLecwt induced secretion of IL-10 in PBMCs of birch pollen allergic donors.

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关键词

Bet v 1,Banana lectin,Allergy,Allergen immunotherapy,Caco-2,THP-1 cells

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