Sex Differences in Neuromuscular Aging: The Role of Sex Hormones

The menopausal transition accelerates neuromuscular ageing in females compared to males. Males and females experience different trajectories of neuromuscular function across the lifespan, with females demonstrating accelerated deconditioning in later life. We hypothesize that the menopause is a critical period in the female lifespan, during which the dramatic reduction in sex hormone concentrations negatively impacts synaptic input to the motoneuron pool, as well as motor unit discharge properties.